Copa Airlines is a full-service carrier, the flag airline of Panama. It is headquartered in Panama City. It operates more than 326 daily scheduled flights to 75 destinations in 31 countries around North, Central and South America, and the Caribbean from its main hub at Tocumen International Airport. Copa is a member of the Star Alliance.

Gol Airlines operate a growing network of 61 destinations (51 domestic and 10 international). Its main hubs are São Paulo–Congonhas Airport, Rio de Janeiro-Galeão International Airport and Brasília International Airport. GOL has a young, modern fleet of 120 aircrafts Boeing 737-700 and 737-800 Next Generation (NG).